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Topigen (Topiramate)
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Topiramate

Topigen is an anticonvulsant medication used in the treatment of epilepsy and migraine headaches. Topigen is also commonly used off-label to treat a wide range of mood disorders, eating disorders, and to aid in substance abuse therapy. While Topigen's mechanism of action is unclear, we know that the drug blocks sodium channels in the body that deliver electrical impulses to excitable cells (such as nerve, muscle, and brain cells). By doing so, Topigen appears to enhance the activity of a chemical messenger (neurotransmitter) known as gamma-aminobutyric acid (GABA).

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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From that time this thesis for the cells of human origin was not disproved. Partition coefficients (log D and log P) and molecular surface area (PSA) are potential predictors of the intestinal permeability of drugs.

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Tensile tests performed in situ in a focused-ion beam scanning electron microscope on Cu nanowhiskers reveal strengths close to the theoretical upper limit and confirm that the properties of nanomaterials can be engineered by controlling defect and flaw densities. Toxic pulmonary edema during influenza developed 3 hours after infection of mice with concentrated influenza viruses adapted to lung tissue. Rats were given either 0 or 100 parts/10(6) fluoride in drinking water for 6 weeks to allow the formation of fluorotic mineralizing tissues. However, for each chain, the nu(1/2) and T(1) measurements indicate a small reversal in mobility at C-10 relative to C-9 before motional freedom again steadily increases on each chain starting at C-11. Triglycerides and Open Angle Glaucoma - A Meta-analysis with meta-regression.

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As the primary test, high performance liquid chromatography is increasingly used and haemoglobin electrophoresis less so with isoelectric focussing being largely confined to screening programmes and referral centres, particularly in newborns. To assess the efficacy, safety and tolerability of oral terbinafine in short-term treatments (1-, 2- and 4-week treatment) of Tinea capitis in children. 4,4-Difluoro-8-(4-iodo-phen-yl)-1,3,5,7-tetra-methyl-3a-aza-4a-azonia-4-borata-s-indacene. To the best of our knowledge, this is the third reported case of AIDS presenting as testicular tuberculosis. The data obtained suggest that ascorutin should be combined with compensatory doses of thiamin.

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Our aim was to gain insights that may help general practitioners understand why people smoke, and why smokers stop and then remain quitting and, from this, to find fruitful approaches to the dialogue about stopping smoking. Tick macrophage migration inhibitory factor (MIF) was first identified in A. Poor self-rated health was also associated with lower life satisfaction, but, this association was moderated by neuroticism, such that those with poor-rated health and low neuroticism did not show lower live satisfaction.

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However, this inflammation was limited and did not merge on surrounding tissues. Experiments have been conducted in order to evaluate the performance of the method with a matching error analysis. To make use of their ability to affect light propagation in an unprecedented manner, plasmonic nanocomposites should consist of densely packed metallic nanoparticles. Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma.

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The temperature conditions and ultrasound influences were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FT-IR). The BRIGHTER study results confirmed the long-term efficacy and safety profile of PRN dosing driven by individualized VA stabilization criteria using ranibizumab 0.5 mg in patients with BRVO. Quantification of silicon content in leaf tissues using inductively coupled plasma optical emission spectroscopy (ICP-OES) confirmed significantly higher silicon concentrations in plants treated with K2SiO2 compared with control plants. The recessive nature of the ccb-1 mutation, together with its specific effect on light induction of the carotenoid biosynthesis genes, indicate that the gene product of ccb-1 acts as a repressor of transcription in some light-regulated processes, but not others.

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A descriptive study of marrow aspirates of 303 children (aged 6-60 months) with severe anaemia and 22 controls (children undergoing elective surgery) was conducted at hospitals in southern Malawi (2002-04). The purpose of this study was to determine the impact of the African Caribbean race on the variability of risk factors for glaucoma in an urban Canadian screening population. Microbial ecology of the dark ocean above, at, and below the seafloor.

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The importance of long-term records in public health surveillance: the US weekly sanitary reports, 1888-1912, revisited. High-throughput arrays identify distinct genetic profiles associated with lymph node involvement in rectal cancer. Beside an unilateral combined nevus sebaceus and verrucosus of the face, neck and skull and an aplasia of a rib there were marked ocular symptoms. Separation was performed on a 50 cm x 75 microm uncoated capillary with 0.5 mmol/L borate solution (pH 9.

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Pathological left-handedness revisited: dichotic listening in children with left vs right congenital hemiplegia. An efficient substitution reaction for the preparation of thyroid hormone analogues. In this article we will review the pathogenesis of inflammatory bone loss and explore the possible interventions to prevent it. MFS patients suffer from many problems at younger ages and with higher frequencies than the general population because of the degenerative nature of the genetic condition. Diagnostic barriers for somatic symptom disorders in primary care: study protocol for a mixed methods study in Germany.

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Factor analysis supported a three-factor model similar to the a priori dimensions. An increasing amount of data supports the existence of cells functionally defined by their self-renewal ability and tumor-initiating potential upon serial transplantation.

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The relations between phonological processing abilities and emerging individual differences in mathematical computation skills: a longitudinal study from second to fifth grades. However, the magnitude of period doubling within these frequency regions was dependent on the chromatic properties of both the test stimulus and the pre-stimulus adaptation. Methods of quantitative analysis with the aid of fluorescence-marked antibodies Hospital utilization and increasing old age in the user of care? The use of a semi-automatic computerised procedure for the study of genetically determined variation in the vectorcardiogram.

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To determine whether the association between acanthosis nigricans (AN) and hyperinsulinemia is independent of obesity and other variables. These cellular aggregations were similar in appearance to the mesenchymal blastemas that form in adult echinoderms prior to their arm regeneration, and to those described in other deuterostomes that undergo regeneration. Tuberculosis (TB) is the most common opportunistic infection worldwide in human immunodeficiency virus (HIV)-infected patients. These results indicate that a large bilateral pleural effusion can elevate intrapericardial pressure sufficiently to cause RVDC and, perhaps, lead to misdirected therapy of an otherwise insignificant pericardial effusion. Minimally invasive or conventional valve surgery: operations prevailing in 2020--the middle ground.

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Still, the size selection through agarose gel electrophoresis separation is a labor-intensive bottleneck of these protocols. Considering all the flow data within each group after torsion repair, increasing time of torsion was associated with significantly less return blood flow in both adult and prepubertal animals.

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We describe this practice as it is depicted on a painting on a rarely exhibited ancient Egyptian artefact. The patient showed no evidence of recurrence after excision of thymic metastasis during one year of 0.2 mg levothyroxine suppression therapy.

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A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution. Sudden unexpected sneezing during the insertion of peribulbar block under propofol sedation.

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Three hundred and thirty five Han Chinese (102 HTG and 233 healthy control subjects) in Chengdu area were studied using PCR-RFLP analysis. The paper reviews the relevant literature on knowledge brokering, and then describes the evolving role of knowledge brokering in this knowledge network. GFAP immunoreactivity was mainly increased in the ganglion cell and inner plexiform layers.

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Evaluation of Potential Drug-Drug Interaction Between Delayed-Release Dimethyl Fumarate and a Commonly Used Oral Contraceptive (Norgestimate/Ethinyl Estradiol) in Healthy Women. Acid-base disturbances in arterial blood and cerebrospinal fluid in patients with chronic respiratory failure. The heart is a principal target of thyroid hormone, and a reduction of cardiac thyroid hormone signaling is thought to play a role in pathological ventricular remodeling and the development of heart failure. Accuracy of the 64 multislice computed tomography in the diagnosis of coronary stent restenosis It is for example not known which proteins function as substrate for the different mono-ARTDs.

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Lithiation Thermodynamics and Kinetics of the TiO2 (B) Nanoparticles. Cystic fibrosis associated with malnutrition and a transient defect in peripheral neutrophil chemotaxis was diagnosed. Asymptomatic meniscal tears are common and are frequent incidental findings on knee MR imaging of the middle-aged or older patient. Indeed, the proportion of species pairs showing: (i) no significant interspecific association increased with species richness, (ii) segregation decreased with species richness, and (iii) small-scale interspecific interaction decreased with species richness.

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To the best of our knowledge, this is a unique case describing the successful placement of dental implants in a patient with PD treated with bisphosphonates. Treatment of bone and joint tuberculosis of the hip by the method of joint excision-reconstruction This test-system is sensitive to melatonin at concentration of 25.1 mg/ml and higher.

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Activation of cardiac caspases: a double-edged weapon implicated in cardiac dysfunction The state of otorhinolaryngological organs in malformations of the jaws

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The parasite presents high genetic variability with seven discrete typing units (DTUs): TcI-TcVI and Tc bat. Some studies showed positive effects of this intervention among these three groups of patients. Multifunctionality and control of the crumpling and unfolding of large-area graphene. Surprisingly, the regulatory methylated region is contained in an unusually large intron that is conserved in IBM1 orthologues.

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Audit of 200 consecutive aortic aneurysm repairs carried out by a single surgeon in a district hospital: results of surgery and factors affecting outcome. Teeth fracture among visually impaired and sighted children of 12 and 15 years age groups of Udaipur city, India--a comparative study.

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The LA transport was strongly dependent on the pH value, being accelerated in the acidic pH range. Transport properties, Lyapunov exponents, and entropy per unit time. The active immunization of albino rats against pargyline (a MAO B inhibitor) induced the formation of antibody to pargyline and results in deep depressive changes and fear.

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The aim of the present study was to assess whether a videolaryngoscope would provide better laryngeal exposure than conventional laryngoscopy and therefore facilitate intubation in cases of difficult laryngoscopy. Peculiar malformation of the genitals of a newborn female infant

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The MSX1 gene plays a key role in odontogenesis regulation, particularly during early stages. On comparing C-banding patterns of Elymus species with their diploid ancestors (Pseudoroegneria and Hordeum), there are indications that certain chromosomal re-arrangements had previously occurred in the St and H genomes. Study of depressiveness with Beck Depression Inventory in patients with cardiac arrhythmias

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Despite encouraging clinical results with next generation drugs (MDV3100 and abiraterone) that inhibit androgen receptor (AR) signaling in patients with castration-resistant prostate cancer (CRPC), responses are variable and short-lived. Lock and key binding of the HOX YPWM peptide to the PBX homeodomain. Strains were selected from the pretransplantation and post-transplantation periods and endotoxin was extracted. Oxygen tension and vascular density in adenocarcinoma and squamous cell carcinoma of the uterine cervix.

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Previous research in a retrospective community-based study suggested that some relatives had difficulty coping with their bereavement when the pre-bereavement period had not been managed well. Disruptive behaviors of older adults in an institutional setting. Variations in endotracheal cuff pressure in intubated critically ill patients: prevalence and risk factors.

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Upper intestinal surveillance in familial adenomatous polyposis. Gadoxetate disodium-enhanced MR imaging: differentiation between early-enhancing non-tumorous lesions and hypervascular hepatocellular carcinomas. The results suggest that sustained hyperglycemia may stimulate the synthesis of new transport receptors (carriers). To compare the effectiveness of age-based formula (ABF) and height-based formula (HBF) for pediatric cardiac patients, including patients with failure to thrive (FTT).

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A fundamental understanding of the thermal effects on nanofluid behaviors is critical for developing and designing innovative thermally responsive nanodevices. Alternatively, sympathetic activity to resistance vessels in skeletal muscle may not be a proper reflection of autonomic cardiovascular control in pregnancy. Normal bovine and human cartilage articular surfaces were extracted for 5 min with 4-M guanidine HCl solution. The biosensor was fabricated using the layer-by-layer assembly approach, by immobilizing a layer of NEST on top of multilayers consisting of a polyelectrolyte (poly-L-lysine) and an enzyme (tyrosinase).

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Hepatocyte growth factor prevents advanced glycation end products-induced injury and oxidative stress through a PI3K/Akt-dependent pathway in human endothelial cells. The optimal simultaneous contrast between gray and white matter and between CSF and gray matter was obtained on images with moderate T2 weighing, with a TR of 3.6 seconds and a TE of 45 msec.

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In addition, the cytotoxic activity of compound 1 was evaluated using human lung cancer cell A 549. For each case, up to ten controls were randomly selected after matching for sex, age, practitioner and date of arrhythmia onset. Prediction of pulmonary hypertension in patients with or without interstitial lung disease: reliability of CT findings. This study aims to develop a new molecular MRI method to assess in vivo ESC viability, proliferation, and teratoma formation. 328 consecutive patients investigated for OSA during a 3-month period.

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Thin-layer chromatographic method in comprehensive quantitative serum lipid analysis Automatic data screening: a practcal solution to the multivariate problem in clinical data. In conclusion, alpha(1)-AR density determines velocity and sensitivity of alpha(1)-AR-mediated contraction in VSMCs.

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Limited repertoire of utilized VH gene segments in a VHa3-allotype-suppressed rabbit. The mean effective dose equivalent and effective dose for 11C-carfentanil were 5.38E-03 and 4.59E-03 mSv/MBq, respectively.

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on gestation day 9, 10 with additional groups given one additional dose of dimethadione 12 hr earlier, 12 hr later or two additional doses 12 hr earlier and later. Both methods identified proteins tightly regulated by phosphorylation as well as signal integration hubs, and both types of phosphoproteins were enriched in proteins encoded by disease-associated genes. The above patterns of oligodendrocyte damage in SJL oligodendrocytes were reminiscent of patterns in the MS lesion, leaving us to conclude that perforin may play an important role in the human disease. Plasma partitioning of CPF increased with increases in plasma lipid levels and the increased partitioning of CPF into plasma lipids resulted in less CPF in other tissue compartments. Novel sulfobutyl ether cyclodextrin gradient leads to highly active liposomal irinotecan formulation.

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MicroRNA-184 inhibits proliferation and promotes apoptosis of human colon cancer SW480 and HCT116 cells by downregulating C-MYC and BCL-2. Biological effect of microwave radiations and possible health risks from radar The two groups were similar in age, gender, education, and income.

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It is not impossible that we might soon be confronted with this type of drug addiction. The information from a large number (78) of independent all-atom molecular dynamics trajectories with explicit solvent is combined together to assemble a connectivity map of the conformational transition. Advances in these areas are expanding our options and illuminating pathology in unique ways.

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One form of the inherited, X-linked, bleeding disorder, hemophilia B, resolves after puberty. Stress was attained by immobilization for 2 hours a day, beginning three days before extraction of the upper right incisors and continuing until sacrifice. In spite of the larger number of ovulations following hCG, subsequent events essential for pregnancy were higher with r-hLH, offsetting differences in terms of implanted embryos at 14 days of pregnancy. In contrast, no occupancy was detected in brain tissue, where expression of these genes is virtually absent. In a recent study (Generoso et al., 1985), it was found that the incidence of X-ray-induced embryonic lethality differed markedly between two hybrid stocks of irradiated male mice.

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This study presents an assessment of the risk of introducing CSFV into Spain through the importation of live susceptible animals. A theory of personality should lead to both accurate prediction and interpretive understanding. TK activity was correlated with the activity of thymidine synthase, which is a key enzyme for pyrimidine synthesis in the de novo pathway. Between 2003 and 2006, 430 patients underwent EERP for localized prostate cancer. The specific functions of numerous genes during embryogenesis are known, and the involvement of their mutations in the pathogenesis of congenital defects is being extensively studied.

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In most countries, rates of suicide in prison are higher than those reported in the general population, and seemingly on the increase. The ratio by CFD modelling was about 1.18 for a 500kW small fire, being near to and a bit lower than the theoretically estimated value of 1.26. Impact of alcohol septal ablation on left anterior descending coronary artery blood flow in hypertrophic obstructive cardiomyopathy. Painless childbirth through extradural anesthetics in retard vehicles Also, ETE does not necessarily indicate a significantly increased incidence of axillary recurrence.

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Knowledge, hygiene behavior and risk of bloodborne infections in the selected staff of beauty parlors and hairdressing salons An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats. Hypofractionated radiotherapy was performed after three-dimensional CT planning with a median total dose of 2016 mercedes-benz metris review 20 Gy in a single department.

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