Tolerade, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Tolerade does not affect mood or arousal, but may cause sedation. In depressed individuals, Tolerade exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Tolerade and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Tolerade has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Tolerade may be used to treat depression and nocturnal enuresis in children. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD).
Other names for this medication:
Imipramine,
Tofranil,
Antidep,
Depramine,
Depranil,
Deprinol,
Depsonil,
Imidol,
Imipramina,
Impril,
Janimine,
Melipramin,
Talpramin,
Tolerade,
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We investigated whether hemodialysis (HD) patients prefer standard or renal-specific oral lansoprazole coupon nutritional supplements (ONS). By competitive radioimmunoprecipitation assays, an experimentally induced anti-2,2,7-trimethylguanosine (TMG) cap structure mAb inhibited the reaction of these antisera. It is possible that this increased estrogen exposure is responsible for the augmented risk of breast and endometrial cancer observed in obesity. Iron supplementation increased MnSOD protein levels and activity in the non-TNF treated cells but did not influence the ability of TNF to induce MnSOD in IEC-6 cells. Tim17 and Tim23 are necessary for initiating translocation, whereas Tim44 and mitochondrial Hsp70 are indispensable for complete transport of preproteins and for unfolding of folded domains of preproteins.
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Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death. We therefore undertook a study of the structural basis for the difference in Ab levels in the various gamma4 alleles. The clinical responses were evaluated by the positive and negative rating scale. Associated clinical features include cutaneous eruption, fever, multiple peripheral lymphadenopathies, and potentially life-threatening damage of one or more organs. The cumulative healing rate was higher in rats given ibiamox dosage for infant rebamipide alone or those given rebamipide and cimetidine during and after administration, but not in rats given cimetidine alone, compared to control rats.
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