Tolerade, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Tolerade does not affect mood or arousal, but may cause sedation. In depressed individuals, Tolerade exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Tolerade and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Tolerade has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Tolerade may be used to treat depression and nocturnal enuresis in children. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD).
Other names for this medication:
Imipramine,
Tofranil,
Antidep,
Depramine,
Depranil,
Deprinol,
Depsonil,
Imidol,
Imipramina,
Impril,
Janimine,
Melipramin,
Talpramin,
Tolerade,
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