Tafenil is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Tafenil and its more potent active metabolite 2-hydroxyTafenil competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression.
Other names for this medication:
Flutamide,
Andraxan,
Drogenil,
Etaconil,
Flutamida,
Flutan,
Ftda,
Fugerel,
Odyne,
Prostamide,
Prostandril,
Tafenil,
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