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Cell and molecular biological studies of p53 functions over the past 30 years have been complemented in the past 20 years by studies that use genetically engineered mice. Multivariable predictors of postoperative cardiac adverse events after general and vascular surgery: results from the patient safety in surgery study.

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A understanding of the biology of normal and abnormal nephrogenesis will ultimately lead to earlier diagnoses of renal malformations and will make it possible to conceive of therapeutic strategies that may enhance the differentiation and survival of metanephric precursor cells. The results showed that the difference and regularity of species richness, and the diversity and evenness of the arthropod community at different time were obvious. The aim of this study was to assess the middle ear effusion and audiological characteristics in children with adenoid hypertrophy and compare the various assessment methods.

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Comorbidities significantly modulate progression and complications of atrial fibrillation. The family as window onto the world of the patient: involving patients and families in the decision-making process. Nanoliposomal si-survivin may significantly reduce the expression level of survivin and inhibit cell proliferation of colon cancer cells in vitro and in vivo.

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Nationally representative surveys show recent increases in the prevalence of overweight and obesity among women of reproductive age in Bangladesh, Nepal, and India. The present results also point to a rapid involvement of semantics in the naming of numerals, also when the numerals are words. While variations in the magnitude and spatio-temporal aspects of signaling by a growth factor can generate different body patterns, how these signaling variations are organized and coordinated during development is unclear. A significantly higher percentage of ossified tissue was found in the fluoride treated callus.

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At 18 months after the discharge, left perinephric abscess was not seen and DM was well controlled with insulin. A series of 68 patients aged 3 months to 18 years treated for the sequele of septic arthritis of the hip in neonatal period at the Orthopedic Department in Lodz between 1964 and 1993 is presented.

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In order to corroborate this mechanism, the distribution of anaphylatoxin receptors in the different cell types of rat liver was determined by quantitative RT-PCR with primers specific for the rat C5a receptor (rC5aR) using RNA isolated from KC, sinusoidal endothelial cells (SEC), hepatic stellate cells (HSC) and HC. In the developing animal, intraperitoneal injections of kainic acid (KA) lead to a prolonged initial seizure followed by chronic recurrent seizures and long-term hippocampal dysfunction. In this work, we describe the use of VIIISelect, a commercially available affinity adsorbent designed specifically for the purification of FVIII compounds. To date, the NMDA receptor subunit 2B (NMDAR2B) was thought not to be expressed in adult cerebellum.

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Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Taken together, our findings support a model in which the evolution of the bipolar mating system was initiated by an ectopic recombination event mediated by similar repetitive centromeric DNA elements shared between chromosomes. Pre-transplant HCC and duration of drain insertion were independent risk factors for the occurrence of repeated infection episodes. In our experience, comprising 151 orthotopic transplants, five patients presented with graft rejection characterized by a lymphocytic vasculitis that did not respond to conventional therapy.

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Modic changes on MR images as studied with provocative diskography: clinical relevance--a retrospective study of 2457 disks. Placenta is a critical organ that synthesizes several growth and angiogenic factors for its own growth as well as fetal development. Selection of high affine peptide ligands for detection of Clostridium Tyrobutyricum spores. The recombinant replica of this antigen might be a valuable tool for inclusion in the development strategy for a diagnostic test. A case of posterior spinal ligament rupture associated with a general anaesthetic for a laparoscopic cholecystectomy is reported.

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The regulation of the pacing strategy remains poorly understood, because much of classic physiology has focused on the factors that ultimately limit, rather than regulate, exercise performance. An analysis of the data relating to oral health status and previous treatment provision suggested that some indicators were easy to accurately record while others lacked clear diagnostic criteria.

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Treatment with statins prior to ICH failed to show a significant impact on outcome in this analysis despite lower haematoma volumes. Can spermatozoa respond to changes in their redox status with the selective activation of gene transcription?

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Consistent with predictions, the system was transformed into an intraguild predation system with the consequent extinction of one spider species. Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells. The management of osteoporosis-induced fractures in hospitals, the prevention and treatment of osteoporosis in primary care and the prevention of falls should be seen as priorities for the NHS to help reduce the burden of disease from osteoporosis in the elderly. Correction of bladder weakness in prolapse of the genital organs For a cathode-ray tube source, the beam spot size, target angle, and source shielding all determine the final valley-to-peak dose ratio.

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Then the fluff injection in a blast furnace tuyere is theoretically analysed with a mathematical model. A paradox was noted in the employment status and income association, one would expect higher levels of migraine in a low-income population, but higher numbers were found in those employed vs unemployed.

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General relativistic gravitational field of a rigidly rotating disk of dust: Axis potential, disk metric, and surface mass density. By this method, the data points in two such data sets are divided into subpopulations using a binary classification tree generated from the data. Electrocardiographic findings in acute and chronic pulmonary diseases in the second and third stages of childhood An irregular secretion and a higher daily mass production of prolactin in patients with NPG could explain both galactorrhea and infertility. Adenine nucleotide- and 2,3-diphosphoglycerate metabolism in human erythrocytes in chronic kidney insufficiency

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Only multimeric recombinant syndecan-4 core protein, but not the monomeric protein, potentiated the activity of PKCalpha, and only oligomeric syndecan-4 cytoplasmic peptides were active. From the family universe to the outside world: family relations, school attitude, and perception of racism in Caribbean and Filipino adolescents. hsRPB7 sequence and function are strongly conserved with its yeast counterpart because its expression can rescue deletion of the essential RPB7 gene at moderate temperatures.

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Taken together, the data available suggest a possible role for this factor in development, stem cell regulation and oncogenesis. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound. The results suggest that both the sex and state of the infant are important moderators of the relationship between measure of visual attention and other individual difference variables.

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However, the mechanisms driving their ordering are not understood. The primary cytotoxicity in ultraviolet-a-irradiated riboflavin solution is derived from hydrogen peroxide. Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy. The transmission loss of vibration acceleration between the tool handle and wrist was 45 dB for grinding and 29 dB for hammering.

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One of the most uncommon stress lesions of the shoulder in adolescents is an avulsion of the lesser tuberosity of the proximal humerus. Indacaterol (arcapta neohaler) for chronic obstructive pulmonary disease. Changes in hydration, protein and proteoglycan composition of the collagen-keratocyte matrix of the bovine corneal stroma ex vivo in a bicarbonate-mixed salts solution, compared to other solutions. Variability in phytic acid content and protein digestibility of grain legumes.

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SIM offers excellent imaging of embryos from three major vertebrate systems in developmental biology: mouse, chicken, and frog. Functional status of patients after surgical myocardial revascularization Overweight and obese individuals have a genetic predisposition, but different expression of genetic loads could be one of the possible explanations for different susceptibility to increase of fat mass and body mass index. To make the process more available to the structural fabrication industry (buildings and bridges), being able to model the process to determine the highest speed of advance possible that will not cause unwanted welding defects is desirable.

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Features of the formation and dispersion of flammable mixtures created by the gas dissipation were examined using a 3D CFD model. Diagnosis and selection of surgical procedures in management of open bite. Dichotomy of the hydrogen atom in superintense, high-frequency laser fields. In controlled studies, general recommendations for prophylaxis were shown to inhibit reinfection. Interestingly, many proteins which are not involved in nucleic acid binding possess large positive patches on their surface as well.

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Shockwave treatment was no more effective than conventional physiotherapy treatment when evaluated three months after the end of treatment. Our aim was to assess whether microdialysis can be used to detect impaired vascular inflow by metabolic changes in the liver. Using sib-pair linkage analyses, no evidence for linkage was found between the D2S1237 marker at this locus and fasting insulin, insulin-stimulated glucose uptake in vivo, obesity, or non-insulin-dependent diabetes mellitus. We developed a general strategy for labeling expressed membrane proteins with a peptide epitope tag and detecting the tagged proteins in native cellular membranes.

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Physicians should be aware of life-threatening adverse effects of apparently innocuous drugs. Cost-effectiveness analysis of the treatment of chronic hepatitis C A systematic monitoring of the cultivated soil ecosystems must include bacteriological parameters together with chemical indices of organic pollution in order to obtain information adequate for assessing their overall quality. General anaesthetics and their effects on GABA(A) receptor desensitization. Neural control of micturition in man examined with single photon emission computed tomography using 99mTc-HMPAO.

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To assess these concerns, a review of mortality in a large series of patients following low-probability lung scans was performed. This relationship was shown to exist independently of 2-month functional status. In conclusion, the H5N1 viruses isolated in Japan, Russia and Hong Kong were derived from a common ancestor virus belonging to genotype V that was generated from genetic reassortment events between viruses of HA clades 2.3.2 and 2.3.4. Statistical designs in combination toxicology: a matter of choice. We reviewed 1,061 operations performed at our institution between 1997 and 2010 and registered as hypospadias repair.

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In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. Q-branch linewidths of N2 perturbed by H2: experiments and quantum calculations from an ab initio potential. Detailed comparison with other kinetic studies was made, and a comparison with thermal transitions observed in alpha-chymotrypsin by using physical techniques was attempted.

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Pansinusitis of the face caused by Streptococcus milleri with cerebral thrombophlebitis after naso-sphenoid surgery of the pituitary gland This has produced an orientation which is more concerned with supporting young people in the process of becoming adults rather than giving attention to their contemporaneous experiences and needs. By using this approach, we have identified and cloned a DNA fragment duplicated in the p(un) mutation of the mouse pink-eyed dilution locus (Brilliant et al., Science 1991, 252, 566-569).

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Molecular consequences of this dynamic modification vary between targets and include alterations in protein/protein or protein/DNA interactions, changes in localization, enzymatic activity, or stability. Mangotoxin is an antimetabolite toxin produced by certain Pseudomonas syringae pv. The murine Unp proto-oncogene encodes a nuclear ubiquitin protease whose overexpression leads to oncogenic transformation of NIH3T3 cells. Bradyzoite-specific gene expression in Toxoplasma gondii requires minimal genomic elements. The strength of avoidance for the space use of predators generally did not correspond to the relative predation threat from those predators.

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All nursing staff need to be aware of the detrimental effects of anxiety on asthma control, so that early symptoms of anxiety can be identified and addressed quickly. Furthermore, it has been shown that two related protein from other parasitic platyhelminths (Fh15 from Fasciola hepatica and Sm14 from Schistosoma mansoni) are able to confer protective inmunity against experimental infection in animal models.

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Problems of protection in the use of sealed radioactive sources in the contact interstitial and intracavitary curie-therapy BuChE-positive neurons without ChAT were found in close proximity with ChAT-positive neuropil in areas such as the thalamus and amygdala. Soil factors exhibit greater influence than bacterial inoculation on alfalfa growth and nitrogen fixation. High suspicion is required for early diagnosis and antiviral treatment, allowing for the frequent hepatic decompensation among cirrhotic patients.

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The pattern of results suggested the operation of a social facilitation effect, as highly skilled monitored participants keyed more entries than highly skilled nonmonitored participants. Histochemical and biochemical research on experimental heteroplastic bone grafts The prevalence of mite allergen was studied in homes in which the indoor relative humidity may be increased by use of an evaporative cooler. Results of treatment of cancer of the oral cavity in the material of the Institute of Oncology in Cracow

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The pathophysiology, causes of thrombocytopenia and clinical presentation have been reviewed briefly. Origin of the Sox multienzyme complex system in ancient thermophilic bacteria and coevolution of its constituent proteins. Radiotherapy planning for the lymphomas: expanding roles for biologic imaging.

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The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. We previously reported that acute treatments with inhaled CO inhibit vascular inflammation and hypoxia-induced vasoocclusion in sickle cell disease mouse models. Though similar results have been found for photodynamic treatment with external porphyrin-based photosensitizers, this is the first report about induction of the genes described above by (photoactivated) endogenous protoporphyrin IX. Clinical experience with biweekly CHOP plus rituximab chemoimmunotherapy for the treatment of aggressive B-cell non-Hodgkin lymphoma.

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Using knowledge of pharmacodynamic mechanisms, the potentially beneficial and dangerous pharmacodynamic DIs between AEDs and psychotropic drugs with psychotropic medications are summarized for clinicians in practical tables. Intra-dlPAG microinjection of these drugs increased the number of punished licks without changing the number of unpunished licks or nociceptive threshold, as measure by the tail flick test. Residue determination of dichlorvos and related metabolites in animal tissue and fluids. Either prediction model is reliable for a CCU population in general.

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CAV2-deltaE3-Rgp was tested by restriction endonuclease digestion, PCR, DNA sequencing. The capacity of the peptides to bind to major histocompatibility complex class II molecules correlated with the proliferative responses.

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The most-parsimonious tree inferred from random data may also be considerably shorter than the second-best alternative. Abdominal wound dehiscence following gynecologic and obstetric surgery Sleep-dependent hippocampal slow activity correlates with waking memory performance in humans.

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Data from an international collaborative study are used to illustrate the application of this proposed interpretation of the coefficient of variation, and they also provide support for the assumptions used in the mathematical derivation. This case report describes a woman who came for a secondary abdominoplasty and presented intraoperatively with an unexpected large epidermal inclusion cyst.

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Adsorption of nutrients and cadmium by different minerals: experimental studies and modelling. We evaluated the relationship between oxygenation measured 24 hours after extracorporeal membrane oxygenation onset and mortality (2010-2015). A critical commentary and updating of the guinea pig maximization test. Using novel, highly sensitive polyomavirus genotyping assays, we evaluated the prevalence of eight distinct HPyVs in a selection of 51 NETs from different entities.

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