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Estimation of IC50 values in vitro and ED50 values in vivo were used to provide an indication of anti-tumor activity. We conducted a phase II multicenter study on the combination of the DNA-methyltransferase inhibitor 5-azacytidine (5-AZA) and the histone deacetylase inhibitor valproic acid (VPA) in patients with higher risk MDS. At those favorable conditions, the tendency toward the local orientational order favored by packing entropy is amplified and found to play a key role seeding nuclei with the CsCl structure. An exponential model of isometric muscular fatigue as a function of age and muscle groups. Recognition of complex sound signals of different duration in a successive complex

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