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Genoxal (Cyclophosphamide)
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Cyclophosphamide

Genoxal is a potent drug that is primarily used in the treatment of cancer. It belongs to the class of cytotoxic drugs called alkylating agents; these interfere with the growth and replication of malignant cells. Genoxal is found to be useful in the treatment of some skin diseases, particularly autoimmune skin diseases or those associated with some sort of immune disorder.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. Thirteen patients with thoracic disc herniation have been operated on between 1960 and 1984.

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As a step toward addressable ionic delivery circuits, we report on the development of a npn ion bipolar junction transistor (npn-IBJT) as an active control element of anionic currents in general, and specifically, demonstrate actively modulated delivery of the neurotransmitter glutamic acid. In 3 out of these 4, which had angiographically normal coronary arteries, the scintigraphy was negative. The first discovery of a brachiosaurid from the Asian continent.

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Contrast sensitivity functions for sinusoidal gratings of different spatial frequencies and stimulus durations have been determined for both eyes of amblyopic subjects. Neisseria meningitidis, a causative agent of meningitis and septicaemia, expresses type IV pili, a feature correlating with the uptake of exogenous DNA from the environment by natural transformation.

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The study examines the profile of strengths and weaknesses in children with Down syndrome compared to typically developing children matched for nonverbal mental age. Combining lesions of other sources of innervation to the dentate gyrus with an ipsilateral entorhinal lesion at 11 days of age did not alter the response of septohippocampal fibers, as determined histochemically. The summary of these important achievements in hypervalent iodine (III) chemistry is described herein. Multiple-scattering approach to pion double charge exchange at 50 MeV.

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Psychiatric disorders and other health dimensions among Holocaust survivors 6 decades later. Despite slow improvement, many patients do not fully recover from a neurologic crisis, and residual neurologic morbidity can be significant.

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The bone marrow (BM) is an organ extremely efficient in mediating long-term survival of plasma cells (PCs), ensuring an immune humoral memory. Is detrusor instability a premature variant of normal micturition reflex? In addition, all participants completed a follow-up questionnaire in 1998.

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Hand hygiene is an important procedure in preventing peritoneal dialysis-related infections. However, several authors recommend analysing the spinopelvic relation in addition to the SVA. How MeHg interferes with cellular proliferation, migration, and differentiation is poorly understood. Experimental hydrocephalus in young dogs: histological and ultrastructural study of the brain tissue damage.

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Congenital hypoplasia of the right ventricle and tricuspid atresia without cyanosis The effects of acute stress and acute corticosterone administration on the immobility response in rats. The study goal was to evaluate the efficacy and safety of a small dose of propofol for the prevention of nausea and vomiting following third molar extraction. In addition, H/DX-MS enables analysis of large protein complexes at physiological concentrations and provides insight into the solution behavior of these complexes that can not be gleaned from crystal structures. When incubated in the presence of phosphatidylserine, phorbol 12,13-dibutyrate and ATP, intact PKD slowly autophosphorylated in the activation loop but only at Ser(748).

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fumigatus conidia expressed a significantly elevated level of dectin-1. The aspirate contained many small and large papillary cell groups and numerous single tall columnar cells with apical cytoplasmic projections and mild to moderate degree of nuclear pleomorphism. The reducing agent dithiothreitol was also found to be a potent competitor of caracemide inactivation.

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The intra-observer agreement was 0.85 and the inter-observer agreement was 0.85. Therapeutic time window and effect of intracarotid neural stem cells transplantation for intracerebral hemorrhage. This highlights the importance of long-term surveillance of persons irradiated during childhood. We refer to the proposed versatile system of Rotation And Scale Invariant Matching as RASIM. The intensity of depression depended on age, gender, and education level.

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The characterization of these pathways will be helpful for the design of drugs influencing wound healing. Soil dehydrogenase in a land degradation-rehabilitation gradient: observations from a savanna site with a wet/dry seasonal cycle.

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There are many natural situations where strategies can not be represented by a single dimension, including situations where individuals can change their behavior as they age. Schizophrenic patients of the residual subtype can be differentiated from healthy individuals with considerable criterion validity on the basis of paradigms from two different ocular motor systems. To investigate how growth patterns of weight, height and BMI from birth to 7years differ according to maternal pre-pregnancy weight (normal weight, overweight and obesity), with specific attention for sex differences. The following case illustrates the roentgenographic and clinical findings of a condition of interest to the orthopaedic surgeon. Several transcription factors, nuclear receptors, or fusion proteins driving cancer growth could be candidates for proteolysis-based drug-discovery programs.

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However, metastasis to the kidney is relatively common at autopsy. Receptor-specific agonists and antagonists are available, which have helped clarify the effects of tachykinins. In vivo, hCG induced neovascularization in the chicken chorioallantoic membrane assay comparable to the activity of vascular endothelial growth factor. nucleatum proteins (FusoSecretome) and to infer their interactions with human proteins based on the presence of host molecular mimicry elements.

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Most retropharyngeal abscesses, including iatrogenic cases, are caused by trauma. Expression of the apoptotic ligands TRAIL, TNF-like weak inducer of apoptosis (TWEAK), and Fas ligand on lupus T cells was determined, and the role of these molecules in the monocyte apoptotic response was examined. In this study, gene disruptions that increase the biosynthesis of poly-3-hydroxybutyrate (PHB) in the photosynthetic bacterium Synechocystis PCC6803 were identified.

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There is no consensus on the validity of this syndrome as an independent clinical entity. Patients with parenchymal cysts or calcification without hydrocephalus had a benign disorder presenting commonly with seizures.

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Treatment for adult subglottic stenosis is technically demanding and no therapeutic algorithm exists. We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects. Renal segmental microvascular responses to ANG II in AT1A receptor null mice.

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Differences between participants and nonparticipants were examined by t-tests and chi-square tests. After excluding patients who underwent lesion excision before MRI, 99 BRCA1 and 103 BRCA2 lesions in 187 women (mean age, 39.7 and 40.4 years, respectively) were enrolled. Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection. To examine which pathway initiated by TNFalpha is influenced, we tested kinase activity of MAP, PI3K/AKT and involvement of cGMP in endothelial cells exposed to CNP. Photosynthetic oxygen production in a warmer ocean: the Sargasso Sea as a case study.

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Dual-parameter flow cytometry demonstrated that IFN-beta-induced squamous differentiation preceded programmed cell death. Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. We randomly assigned 1637 postmenopausal women with prior vertebral fractures to receive 20 or 40 microg of parathyroid hormone (1-34) or placebo, administered subcutaneously by the women daily.

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Biased hormonal therapy duration analysis makes results uninterpretable. We present 2 cases involving a 9-month-old infant girl and a 14-month-old girl who experienced inflicted traumatic globe rupture. However, light absorption for collagen and connective tissue can hamper the oxidation process.

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Epidemiological data demonstrate that colon cancer incidence is associated mainly with high dietary fat consumption. In this double-blind and placebo-controlled study, patients were randomly allocated to receive either dexmedetomidine, 0.5 microg x kg(-1) (group Dex), midazolam, 0.025 mg x kg(-1) (group Dor), or saline (group C) in a total volume of 20 ml given intravenously 10 min before the induction of anesthesia. Human immunodeficiency virus particles from drug-exposed cells showed lower infectivity than virions from untreated cells. Early geriatric consultation increases adherence to TQIP Geriatric Trauma Management Guidelines. After fractionation by differential centrifugation of frontal cortex homogenates, benzodiazepine and serotonin 5-HT2 receptors were mainly found in the heavy mitochondrial (M) fraction, whereas mu-opiate and muscarinic cholinergic receptors were mainly concentrated in the microsomal (P) fraction.

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We investigated the role of Bmi1 in regeneration of exocrine pancreas. After release of the subscapularis, each patient had less pain in the shoulder and an average increase of 27 degrees of external rotation. Despite the common dogma that nuclear DNA is the primary target for radiation-induced cell death and carcinogenesis, studies conducted using microbeam suggested that targeted cytoplasmic irradiation induces mitochondrial dysfunction, cellular stress, and genomic instability.

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For several, but not all, cellular DNA segments investigated, extensive increases in DNA methylation were found in comparison with the methylation patterns in BHK21 or primary Syrian hamster cells. There is a substantial rise in natriuretic peptides seen with fetal bypass, likely in part a reflection of myocardial dysfunction. In its completed form, this rare syndrome combines the triad of hemiplegia, hemianaesthesia, and homonymous hemianopia. Our data suggest that cbl-b encodes a protein which can interact with signal transduction proteins to regulate their function or to be regulated by them. Group I consisted of 21 children (41 hip joints) who underwent myotomy of the adductor longus, adductor brevis and gracilis muscles.

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Since 2010, eleven interventions have been developed to address patient-specific and provider-specific barriers, many of which are adaptations of the collaborative care model. Nerve membrane current noise: direct measurements under voltage clamp. The patient had concerns for compromised immune system as he was on chronic prednisone and methotrexate therapy. The critical factors in translating macroscale flask-based methods to a flow-based microfluidic method are highlighted and approaches are demonstrated to flexibly fine tune nanoparticle shapes into three broad classes: spheres/spheroids, rods, and extended sharp-edged structures, thus varying the optical resonances in the visible-near-infrared (NIR) spectral range.

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Leveraging prior quantitative knowledge in guiding pediatric drug development: a case study. The effectiveness of prophylactic central neck dissection (pCND) following total thyroidectomy (TT) in patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) is still controversial.

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Vibrational spectroscopy and dynamics of W(CO)6 in solid methane as a probe of lattice properties. Our findings indicate that the different TLRs differ in their immunological redundancy, reflecting their distinct contributions to host defense. Ninety-four percent claimed the procedure was definitely of benefit. Long-distance movement of Arabidopsis FLOWERING LOCUS T RNA participates in systemic floral regulation.

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Priority groups included healthcare professionals, indigenous persons, pregnant women, young children, persons with chronic illnesses and otherwise healthy adults 20-39 years of age. Effect of cerebral circulatory drugs on cerebral and peripheral circulation, with special reference to aminophylline, papaverine, cyclandelate and isoxsuprine. Interactions of azodye carcinogens and azodye carcinogen conjugates with specific proteins in the rat liver. Usefulness of heart rate variability in predicting drug efficacy (metoprolol vs diltiazem) in patients with stable angina pectoris.

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Thermophilic anaerobic Caldicellulosiruptor kristianssonii and Caldicellulosiruptor owensensis contained a linear penta-amine, thermopentamine, and two quaternary branched penta-amines, N4-bis(aminopropyl)spermidine and N4-bis(aminopropyl)norspermidine, as the major polyamines. This shows that TGF-beta1 regulates CD154 expression leading to spontaneous IL-12 production and autoimmunity.

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The use of C1 lateral mass screws in complex cervical spine surgery: indications, techniques, and outcome in a prospective consecutive series of 25 cases. A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function. FDT, SWAP, flicker perimetry, and OCT are all useful methods for discriminating between healthy eyes and eyes with early glaucoma. Long-term augmentin liquid forgot to refrigerate peanut results of congenital glaucoma microsurgery--retrospective study

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