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Effects of atrial natriuretic factor on glucose metabolism in isolated adipocytes. Synthesis and characterization of a dianionic carbohydrate-based phospholipid. Compared to the interaction with C4b, we conclude that binding of C3b to C4BP requires larger molecular surface on C4BP. A genetic analysis of secretory pathway function in yeast was initiated some 12 years ago in the laboratory of Randy Schekman.

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2,4-dimethoxybenzyl as a protecting group for glutamine and asparagine in peptide synthesis. Manipulation of episodic recall difficulty and analysis of trials when recall failed indicated that these task (i.e., episodic vs. While the effects of cryopreservation on motility, morphology and viability of sperm are documented, the question of the probable alteration of sperm DNA, chromatin and acrosome integrity after freezing and thawing procedures in different methods is still controversial. Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls.

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Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique. These multipurpose excipients have dramatically reduced the number of incorporating excipients in the tablet.

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Effects of acupuncture therapy on abdominal fat and hepatic fat content in obese children: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. On the control day 5-h antroduodenojejunal manometry was performed. Urecholine prophylaxis for urinary retention in anorectal surgery. Rabbit lacrimal gland epithelial cells (RLG cells) were incubated with NO donors and/or NOS substrates and the protein released into culture medium was determined with bicinchoninic acid assay. Significant amounts of di(2-ethylhexyl) phthlate (DEHP) leach into blood stored in DEHP-plasticized PVC bags.

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Cost-effectiveness analysis of prescribing behavior before and after an educational intervention. Therefore, self reported weight can be used as approximation for real body weight in elderly ED patients presenting with non-specific complaints. The evolution of demographic processes (natality, mortality, life expectancy) affected the age gender structure of population of the republic. Cough is due to activation of sensory receptors in the larynx and lower respiratory tract, sending impulses to the brainstem. This was predominantly related to victims of traffic accidents, whereas male victims clearly dominated.

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Exposure of platelets to thrombin, in the presence of 1 mM calcium, induced increased membrane association of PKC-alpha, -beta, and -zeta, while the subcellular distribution of PKC-delta remained unaltered. Three model recombinant proteins, human serum albumin (HSA), bovine granulocyte colony stimulating factor (bGCSF), and human fibroblast growth factor-20 (FGF-20) that display a range of isoionic points have been selected for this study. The PFNA blade appears to provide additional anchoring in osteoporotic bone. Insight into the experience of family-member decision making regarding treatment of incompetent ICU patients can be gained through an exploration of the literature regarding the ICU environment, normative bioethics, and the decision-making process (see Fig. In the past, the three general approaches for assessing the presampled MTF were using the angulated slit, angulated edge, and angulated square-wave test pattern all of which are tilted slightly against the column direction of the detector.

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We assessed the specific preoperative sonographic and urinary factors that may be important in predicting renal function outcomes after pyeloplasty. Kinetic parameters of glutamine synthetase (GS) and glutamate synthase (glutamine-oxoglutarate aminotransferase) (GOGAT) activities, including initial velocity, pH, and temperature optima, as well as Km values, were estimated in Schizosaccharomyces pombe crude cell-free extracts. The digital divide: Examining socio-demographic factors associated with health literacy, access and use of internet to seek health information. Ageing was shown to accelerate the gastric and small intestinal transit significantly.

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The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model. A Palmaz stent had dislodged into the left pulmonary artery after TIPS. This is an easy-to-perform technique which offers good results and although it has some limitations, it can be recommended for the treatment of many peripheral corneal defects (perforations and significant thinning).

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The univalents segregate in anaphase only after the autosomes approach the poles. Using techniques developed in our laboratory, we investigate the impact of convection, step changes in bulk concentration, and interfacial mechanics. The kilovoltage settings providing clinically acceptable images were assessed individually by 12 observers.

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Also, considerable differences were found in spinal motor neuron morphology, with A/J and CSS1 showing smaller, possibly less developed, motor neuron axons compared to all other inbred strains. Adaptive evolution of the response to hyperthermia has led to different results depending upon the species. Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distribution. The assessment of whether, and to what degree, a drug causes changes in body weight is not straightforward, since clinical studies performed during a drug development program are not designed to measure changes in body weight. The sensitivity of this imaging system to defocus about the special imaging condition that yields an enhanced dynamic range is examined, and it is shown that the modulation transfer function (MTF) degradation when the magnitude of misfocus is increased past this condition is much more gradual than the degradation of a conventional imager past a zero-misfocus state.

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The dynamic interaction between nuclear proteins and chromatin leads to the functional plasticity necessary to mount adequate responses to regulatory signals. Spatial resolution, signal-noise ratio and, contrast-detail visibility were evaluated by phantom measurements in grid controlled pulsed and continuous fluoroscopy.

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The clones with high-binding force with human CD133 were then identified by sandwich ELISA and their single-stranded DNA was extracted to test the specificity by competitive ELISA. Here, we exploit the molecular mechanisms of caspase activation and tyrosine kinase/adaptor protein signaling to forge a unique approach for selectively killing leukemic cells through the forcible induction of apoptosis. It is therefore desirable for unstimulated cells to have a negative control mechanism to keep TCF inactive.

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Despite significantly decreased acute phase proteins in RA, the Lp(a) concentration increased significantly between the two observations in the group as a whole. Increasing evidence that the rewarding effects of energy-dense foods play a profound role in overeating and the development of obesity has heightened interest in studying the genes, molecules and neural circuitry that modulate food reward.

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The compounds NSC 284682 and NSC 659687 were especially effective irrespective of the multidrug resistant phenotype. Virus particles present in the stool of an acutely ill patient (YAM-67) was transmitted intravenously into rhesus monkeys (M. The accounts establish that, mechanically, this is largely due to savings rather than incoming gifts and remittances. OsiriX, a free open-source medical imaging software with powerful three-dimensional (3D) capability, enables neurosurgeons to perform 3D rendering without extensive training. Myoepithelial cells lining ducts of glands at all stages of development are spindle-shaped structures oriented parallel to the long axis of the duct at the base of the luminal epithelium.

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Chloride intracellular channel 4 (CLIC4) and reactive oxygen species (ROS) have been linked with promoting stromal cell transdifferentiation in various cancers, but little is known of their roles in ovarian cancer. Clinical symptomatology was characterized by typical nitroglycerin-responsive crisis of angina pectoris associated to an electrocardiographic pattern of negative T wave on anterolateral and inferior leads. Surgical exeresis associated with radiotherapy in the treatment of cancers of the pyriform sinus The course was delivered in three phases: distance didactic learning, face-to-face training, and 12 months of web-based professional development activities to support integration of skills into practice. In the dialysis unit, where the focus is on handling technology and maintaining life, end of life care may be neglected or overlooked.

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The level of RB mRNA increased slightly in mitotic cells as compared with interphase cells. The pace of research in this field has greatly accelerated over the last decade caused in part by the introduction of molecular methods and the growing recognition of both microbial and nonmicrobial pathogens implicated in this disease process. To test the physiological functions of some of these proteins, ten genes were insertionally inactivated.

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Because insects are relatively simple and accessible to manipulation, they provide good experimental preparations for exploring mechanisms underlying sensory coding and memory. Determination of the molecular weights of hemoglobins and hemoglobin-haptoglobin complexes by means of light diffusion Three thousand one hundred eighty-two malpractice claims were filed during the period of interest.

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Antigonadotropins in the treatment of uterine functional haemorrhage in young women. Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Considerable effort has been devoted to a search for such a signal and to measuring its time course and accuracy.

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Two patients in the prosthetic group developed a recurrent hernia, and 2 required reoperation for bleeding while on ECMO. It is shown that the analyte is incorporated into the matrix crystals for all the sample preparation protocols examined. Genotoxic stress, such as chromosomal breaks or lesions induced by chemotherapeutic agents, result in the activation of the well-characterized DNA damage response pathway. The opgGH mutant strain, which was defective in OPG biosynthesis, initiated the growth at a slower rate in wash waters obtained from spinach, lettuce and green collard and severely impaired biofilm formation.

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The observed and expected heterozygosities ranged from 0.2692 to 0.9667 and from 0.3271 to 0.8881, respectively. Rectal swabs and urine cultures were obtained from patients within 72 hours of admission to the study ward and twice weekly until discharge from the ward or the intensive care unit.

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Similarly, in the prediabetic group, lower IL-10 levels at 48 and 72 h of culture were found. Effects of oestrogen upon nitric oxide synthase NADPH-diaphorase activity in the hypothalamo-neurohypophysial system of the rat. However, the presence of benign prostatic hyperplasia did not increase the risk of ED.

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A research strategy to study and account for gender differences in TB control is proposed. Second-degree type I atrioventricular block in a patient with acute posteroinferior myocardial infarction and syncopal attacks. Altogether, these results demonstrate that MUC4 is a target gene of endodermal TFs and thus point out an important role for these TFs in regulating MUC4 expression during epithelial differentiation during development, cancer, and repair.

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The tabs also were ranked according to the final-color match to the corresponding natural tooth. The surface covalent attachment of indolocarbazole axles enables anion templation to be exploited in the formation of pseudorotaxane assemblies via the threading of neutral isophthalamide macrocycles from solution.

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The quality of tomographic images generated from filtered backprojection depends on the underlying assumptions about the projections. Fibin is expressed in cerebellum, skeletal muscle and many other embryonic and adult mouse tissues suggesting not only a role during embryonic development but also in adult functions. This descriptive study reviewed the computerized administrative records of physician visits and prescriptions dispensed to examine a population-based, cross-sectional cohort of children diagnosed with ADHD or prescribed stimulant medication, or both.

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The molecular approach allowed the visualization of alpha-proteobacteria as major constituents of a bacterial symbiosis within the reproductive system of the Loliginidae. A chromatographic and polarimetric study of the kinetics of degradation. Complex medium additives such as yeast extract or peptone are often used in industrial cell culture processes to prolong cell growth and/or to improve product formation. Our purpose is to describe its current epidemiology in a general surgery (GS) intensive care unit (ICU) where patients are routinely screened and aggressively treated for sepsis by an established protocol. Intestinal damage following a single and fractionated irradiation of fast neutrons

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Despite relatively low interspecific variation, the nuclear data revealed the existence of two major groups roughly corresponding to species with a Western or Eastern European origin. Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. A small, randomized, placebo-controlled trial of the use of antiviral therapy for patients with chronic fatigue syndrome.

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In order to identify complexes that may play a role in invasion we purified detergent-resistant membranes (DRMs), known to be enriched in merozoite surface proteins, and used blue native-polyacrylamide gel electrophoresis (BN-PAGE) to isolate high molecular weight complexes for identification by mass spectrometry. Studies have demonstrated the clinical usefulness of propofol for anaesthesia in horses but the use of a concentrated solution requires further investigation. Early electron microscopic changes in the course of liver injury. The species is believed to be related to dothideaceous black yeasts. Characterization of molten globule PopB in absence and presence of its chaperone PcrH.

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Moraxella lacunata is a rare, usually commensal gram-negative rod most commonly associated with eye infections. These results suggest that, in T cells, activation of PI 3-K is an important step in controlling TNF-alpha protein synthesis in response to growth factors. Detection of csf flow in ventriculo-atrial shunts by cold transfer. Idiopathic PA (IPA) has long been considered an extreme of normal variation, but emerging evidence links IPA to an increased risk of developing the metabolic syndrome (MS) and thus ultimately cardiovascular morbidity. Decision conflict was lower immediately following the use of a computerised decision aid in a shared decision-making consultation than immediately following direct doctor-led advice based on paper guidelines.

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Nickel-catalyzed carboxylation of aryl and vinyl chlorides employing carbon dioxide has been developed. Disjunct species distributions may result from a combination of geologic events and long-distance dispersal. A strong reduction of CPS mRNA levels was observed in glucocorticoid receptor- and C/EBPalpha-deficient mice, whereas the CPS mRNA was normally expressed in C/EBPbeta knockout mice and in HNF3alpha and -gamma double-knockout mice.

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Radiographic studies were then independently evaluated by blinded radiologists for anatomic findings with CA used as the standard. All the rounds of the study were carried out in women and children in the same households. Process modeling and simulation can help engineers design and optimize large-scale systems and operations.

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To identify the differentially expressed genes related to lymphatic metastasis of lung squamous cell carcinoma. Clinical manifestations and course of meningococcal disease in 562 patients.

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An experimental test of the information model for negotiation of biparental care. Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. We have evaluated the efficacies of micafungin, amphotericin B, and voriconazole, alone and in double and triple combinations, in a murine model of systemic infection by Scedosporium prolificans. This is the first study to determine the effect of these polymorphisms on carotid atherosclerosis.

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Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins. Glutamic pyruvic transaminase in rat liver after single injection of carbon tetrachloride. Eight months after placement of the thoracic endograft, the patient presented with an acutely expanding and symptomatic thoracic aneurysm.

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A class of potential multi-chromic (19)F imaging tracers is made by pairing metal ions with a fluorinated chelator. HelP was required for association of PcrA and Ssb with ICEBs1 regions distal, but not proximal, to oriT, indicating that PcrA needs HelP to progress beyond nicked oriT and unwind ICEBs1. This study aimed to evaluate the clinical severity as well as healthcare spending on dissociative disorders (DDs).

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A corpus of 5,765 consonant-vowel-consonant sequences (CVCs) was compiled, and phonotactic probability and neighborhood density were computed for both child and adult corpora. Initiating insulin treatment with basal insulin was effective and safe in Asian T2DM patients in a real-world setting, but insulin needs may differ from those in Western countries. The technique and advantages are somewhat analogous to those of pre-excisional biopsy of a breast mass with use of wire localization performed under mammographic guidance. Induction of tolerance to islet and skin allografts by intrathymic inoculation of thymic stromal cell clones in mice. However, accessions-within-populations differed in the way susceptibility was affected by nutrient supply, and most accessions had a higher susceptibility under nutrient-poor conditions.

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Little is known, however, about the immediate social responses following stress in humans. Enrichment cultures were started with activated sludge obtained from a local wastewater treatment plant where it predominantly treats domestic wastewater.